Clinical Study on Effects of Dentifrice Containing 0.05% Isopropyl Methylphenol (IPMP) and 0.05% Dipotassium Glycyrrhizinate (GK2) on Gingival Conditions
박용덕, 조자원, 서우석, Park Hae-Hoon, 신승철, Sano Hiroshi, Kambara Masaki,
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박용덕 ( Park Yong-Duk ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry & Institute of Oral Biology
조자원 ( Cho Ja-Won ) - Dankook University School of Dentistry Department of Preventive Dentistry
서우석 ( Seo Woo-Seok ) - CJ LION Corp. Best Living Institute
( Park Hae-Hoon ) - CJ LION Corp. Best Living Institute
신승철 ( Shin Seung-Chul ) - Dankook University School of Dentistry Department of Preventive Dentistry
( Sano Hiroshi ) - Japan LION Corp. Product Development Department International Division
( Kambara Masaki ) - Osaka Dental University Department of Preventive and Community Dentistry
KMID : 1157520100060020055
Abstract
Objective: The purpose of this clinical study is to determine the effect of dentifrice containing 0.05% Isopropyl methylphenol (IPMP) and 0.05% Dipotassium glycyrrhizinate (GK2) on improvement of gingivitis related symptoms.
Materials and Method: Double blind clinical study was carried out in 120 healthy Korean adults to evaluate the improvement effect of test dentifrices for 3 month. All subjects (range of age: 23-35) were randomly assigned into 4 groups, 1) control (without both IPMP and GK2), 2) 0.05% IPMP/ 0.05% GK2 group, 3) 0.05% IPMP group and 4) 0.05% GK2 group. All subjects were provided with their assigned test dentifrice and soft-bristled toothbrush for home use. Subjects were instructed to brush their teeth for 3 minutes three times daily using only the dentifrice and toothbrush provided.
Results: After 3 month test period, IPMP/GK2 group showed statistically significant (p＜0.05) reductions for halitosis (17.5%), Plaque index (36.5%), gingival crevicular fluid (34.7%), periodontal pocket depth (13.1%), and Gingival index (16.0%) compared to control group.
Conclusion: The dentifrice containing of 0.05% IPMP and 0.05% GK2 showed the most efficient in improving the gingivitis related symptoms. These findings might suggest that a combination of IPMP and GK2 showed a synergistic effect or special mode of action.
키워드
isopropyl methylphenol (IPMP); dipotassium glycyrrhizinate (GK2); dentifrice; plaque index; gingival index
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